Have you ever taken antibiotics for a cold? Have you eaten conventionally raised beef, chicken, pork, etc? Do you give into temptation for those MUST have comfort foods? Is your mind a little fuzzy? Are you inflamed? Is stress an issue? Do you have health issues that just won’t seem to go away? Maybe, it all has to do with your gut…..
One of the issues we are facing today is being “leaky”; gut, brain, lungs, etc. Usually if one barrier is affected, so are the others. Possibly up to 90% of the American population has some degree of “leakiness”. This may be due to the foods we consume on a daily basis causing gut inflammation combined with the fact that we may be overexposed to antibiotics (both prescribed and the ones that we ingest everyday due to livestock rearing practices).
What do you mean being “leaky”?
We normally have a ratio of 80/20 percent of good to bad bacteria in our body. When antibiotics are used, they end up killing the beneficial bacteria responsible for aiding in the digestion and protection of the intestinal tract. This causes an increase in the ratio of pathogenic bacteria to beneficial bacteria by virtue of the fact that the bad bacteria produce chemicals that further inhibit the re-colonization of good bacteria. These harmful bacteria stay busy by stealing the nutrients we consume, causing fermentation of proteins during digestion, and secreting acid that causes the heartburn and reflux our society is experiencing.
Eventually, the toxic material produced by these bacteria cause inflammation that form holes in the walls of the bowel allowing larger food particles and toxins to enter into the blood stream. Since the body is not used to seeing the large particles of food, they are assumed to be “foreign” and the immune system mounts an attack. This causes allergies to form against that food. More and more sensitivities to foods and chemicals may develop over time as the “leakiness” continues. In addition, if we continually eat foods that we are intolerant to, they may lead to inflammation forming unnatural openings as well.
Finally, autoimmunity may develop since many of these protein fragments look like various organs in our body. The body becomes unable to differentiate the food from the organ and attacks the organ instead. For example, gluten and Hashimoto’s thyroid are highly associated in the medical literature.
How do you avoid a leaky gut?
Determining underlying food intolerances and sensitivities and hidden infections will help avoid consuming foods that cause gut inflammation.
Histamine may also contribute to leaky gut. Histamine is produced by the body in response to inflammatory triggers such as allergies, infections, insect bites, etc. The resulting redness and swelling are a beneficial reaction—it brings blood flow and white blood cells to the site to make repairs. Unfortunately, histamines can become an issue if their production is excessive, uncontrolled, or inappropriate. Anti-histamine drugs are commonly used to temporarily block this uncomfortable response.
Over time, elevated histamine levels may contribute to the creation of zonulin, an inflammatory molecule that contributes to leaky gut by creating gaps between cells. To modulate the histamine response, there are enzymes called DAO and HMNT that help break it down. If a person has genetic issues with these enzymes, that individual may exhibit allergic symptoms such as hives, rashes, insomnia, and sensitivity to some foods and airborne allergens.
How do you test for a leaky gut?
There are advanced functional medicine tests to determine if your gut is leaky such as the lactulose/mannitol test. Cyrex Laboratories has released an Intestinal Antigenic Permeability Screen that helps a practitioner to verify leaky gut.
We can also test for histamine response and and gut inflammation including zonulin and calprotectin. Many times we directly initiate the 4R protocol below in lieu of testing.
How do you heal a leaky gut?
It is best to avoid antibiotics in food by eating organically or buying foods from individuals that don’t use antibiotic feeds. If an antibiotic is taken for an infection, re-colonize the body with probiotics while on the antibiotic and for several weeks/months after it is finished or the Leaky Gut Syndrome may return.
When it comes to folks who have histamine issues, it’s beneficial to eliminate foods that stimulate histamine release or that contain high amounts of histamine, such as alcohol and fermented foods. It’s also important to provide supplementation to support histamine removal.
Depending on the location and severity of the inflammation, leaky gut can be repaired with supplementation. Common supplements include glutamine (although that’s a possible no-no for folks with an issue with the GAD SNP), short-chain fatty acids like butyrate from butter, aloe (although aloe may not be a good choice for those with autoimmune issues), marshmallow root, and others. Kombucha and bone broth (not for glutamate sensitive folks) may also help with leaky gut.
Some folks with extreme gut inflammation or autoimmune issues might require Rx prescriptions. As always, discuss your options with your licensed MD.
We use a “4R” protocol to help alleviate GI problems. This includes removing offending foods/environmental factors and detecting/eradicating infections, replacing whatever the body temporarily needs to help breakdown and digest food, repairing an inflamed gut, and reinoculating the GI system with diet and temporarily offering friendly bacteria probiotics. We sometimes utilize very beneficial yeast to improve the efficacy of these beneficial bacteria as well as improve the gut’s immune system.